Article

Prioritizing and characterizing functionally relevant genes across human tissues

2021-01-22

Abstract excerpt

Knowledge of genes that are critical to a tissue’s function remains difficult to ascertain and presents a major bottleneck toward a mechanistic understanding of genotype-phenotype links. Here, we present the first machine learning model – FUGUE – combining transcriptional and network features, to predict tissue-relevant genes across 30 human tissues. FUGUE achieves an average cross-validation auROC of 0.86 and auP...

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Identifiers and source

Literature Corpus work: 98b75967-0680-56f0-bc84-1e7d97cdb7ef
DOI: 10.1101/2021.01.22.427774

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