Article

ShapeGTB: The role of local DNA shape in prioritization of functional variants in human promoters with machine learning

2018-09-13

Abstract excerpt

Motivation: The identification of functional sequence variations in regulatory DNA regions is one of the major challenges of modern genetics. Here, we report results of a combined multifactor analysis of properties characterizing functional sequence variants located in promoter regions of genes. <h4>Results: </h4>: We demonstrate that GC-content of the local sequence fragments and local DNA shape features play sig...

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Literature Corpus work: 51f0903c-d2e1-5124-8761-24deb4b4b645
DOI: 10.7287/peerj.preprints.27199v1

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