Article

Breast cancer cells promote osteoclast differentiation in an MRTF-dependent paracrine manner

2023-12-08

Abstract excerpt

<h4>ABSTRACT</h4> Bone is a frequent site for breast cancer metastasis. The vast majority of breast cancer-associated metastasis is osteolytic in nature, and RANKL (receptor activator for nuclear factor κB)-induced differentiation of bone marrow-derived macrophages (BMDMs) to osteoclasts (OCLs) is a key requirement for osteolytic metastatic growth of cancer cells. In this study, we demonstrate that Myocardin-rela...

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Literature Corpus work: 2c550ef2-c44b-5b29-8e52-d455bbe77770
DOI: 10.1101/2023.12.06.570453

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