Article

Role of ACTB in Breast Cancer EMT and Metastatic Progression: An Integrated Multi-Omics and Network-Based Study

2025-09-30

Abstract excerpt

Beta-actin (ACTB), a major cytoskeletal protein, plays a crucial role in the epithelial-to-mesenchymal transition (EMT) that facilitates breast cancer metastasis. By driving actin cytoskeletal remodelling, ACTB enables cancer cells to acquire migratory and invasive phenotypes. This study integrates multi-omics data, pathway and protein interaction analyses, and genetic evidence to characterise ACTB's role in breas...

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Literature Corpus work: 24033a32-b0e6-5564-a7ac-489b0c5fad46
DOI: 10.20944/preprints202509.2589.v1

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