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Article

Crohn's Disease Enteritis: Pathophysiological Mechanisms and Therapeutic Approaches.

Scandinavian journal of immunology - 1 Jun 2026

Jia Liping, Wang Hongzhi

Abstract excerpt

Crohn's disease (CD) is a chronic, relapsing-remitting inflammatory condition of the gastrointestinal tract. This review provides a comprehensive analysis of the underlying pathophysiological mechanisms, highlighting the interplay between intestinal epithelial cells, dysregulated immune responses, gut microbiota and environmental triggers in CD. Key genetic susceptibilities (e.g., NOD2, ATG16L1, IL23R) and...

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Source

Identifiers

PMID: 42316543
DOI: 10.1111/sji.70129

Genes

ATG16L1
IL23R
NOD2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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