Article

High Fat Diet Induces Epigenetic 1-Carbon Metabolism and HFpEF

2024-09-16

Abstract excerpt

The chronic high fat dysbiosis diet (HFD) instigates cardiac remodeling, dysfunction and chronic heart failure (CHF). The therapeutic approaches focusing oxidative stress, inflammation and hyperlipidemia have not yielded significant positive clinical outcomes. Recent studies report that although mitochondrial ATP citrate lyase (ACLY) supports cardiac function, however, decreases more in human HFpEF than HFrEF. Int...

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Literature Corpus work: 90927a8b-5934-5994-aff6-408f59ea02ab
DOI: 10.20944/preprints202409.1252.v1

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