Article

Impairments in <i>SHMT2</i> expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activity

2022-04-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Serine hydroxymethyltransferase 2 (SHMT2) catalyzes the reversible conversion of tetrahydrofolate (THF) and serine producing THF-conjugated one-carbon units and glycine in the mitochondria. Biallelic SHMT2 variants were identified in humans and suggested to alter the protein’s active site, potentially disrupting enzymatic function. SHMT2 expression has also been shown to de...

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Literature Corpus work: b1e6e905-b90d-504d-b336-73773a6789ef
DOI: 10.1101/2022.04.07.487511

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