Article

MSX2 safeguards syncytiotrophoblast fate of human trophoblast stem cells

2021-02-03

Abstract excerpt

The majority of placental pathologies are associated with failures in trophoblast differentiation, yet the underlying transcriptional regulation is poorly understood. Here, we use human trophoblast stem cells to elucidate the function of the transcription factor MSX2 in trophoblast specification. We show that depletion of MSX2 de-represses the syncytiotrophoblast program, while forced expression of MSX2 blocks it....

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Literature Corpus work: 9073523c-f51a-56a3-8515-4b8301fbb2da
DOI: 10.1101/2021.02.03.429538

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