Article
Ets2 is required for trophoblast stem cell self-renewal.
Developmental biology - 1 Dec 2007
Wen Fang, Tynan John A, Cecena Grace, Williams Roy, Múnera Jorge, Mavrothalassitis George, Oshima Robert G
Abstract excerpt
The Ets2 transcription factor is essential for the development of the mouse placenta and for generating signals for embryonic mesoderm and axis formation. Using a conditional targeted Ets2 allele, we show that Ets2 is essential for trophoblast stem (TS) cells self-renewal. Inactivation of Ets2 results in TS cell slower growth, increased expression of a subset of differentiation-associated genes and decreased...
Topics
- Alleles
- Animals
- CDX2 Transcription Factor
- Cell Differentiation
- Cell Line
- Cell Proliferation
- Colon
- Embryo Loss
- Gene Expression Regulation, Developmental
- Gene Targeting
- Homeodomain Proteins