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Article

Ets2 is required for trophoblast stem cell self-renewal.

Developmental biology - 1 Dec 2007

Wen Fang, Tynan John A, Cecena Grace, Williams Roy, Múnera Jorge, Mavrothalassitis George, Oshima Robert G

Abstract excerpt

The Ets2 transcription factor is essential for the development of the mouse placenta and for generating signals for embryonic mesoderm and axis formation. Using a conditional targeted Ets2 allele, we show that Ets2 is essential for trophoblast stem (TS) cells self-renewal. Inactivation of Ets2 results in TS cell slower growth, increased expression of a subset of differentiation-associated genes and decreased...

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Identifiers

PMID: 17977525
DOI: 10.1016/j.ydbio.2007.09.024
PMCID: PMC2211385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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