Article

Acute Methylglyoxal-Induced Damage In Blood-Brain Barrier And Hippocampal Tissue

2021-12-10

Abstract excerpt

Methylglyoxal (MG) is a reactive dicarbonyl compound formed mostly by the glycolytic pathway. Elevated blood glucose levels can cause MG accumulation in plasma and cerebrospinal fluid diabetes mellitus and Alzheimer’s disease, where the high reactivity of MG leads to modification of proteins and other biomolecules, generating advanced glycation end products (AGEs) appointed as mediators in those neurodegenerative...

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Literature Corpus work: 906b10b6-953f-5222-82a2-dc82fa796ba4
DOI: 10.21203/rs.3.rs-1104792/v1

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