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Glycation Leads to Increased Invasion of Glioblastoma Cells

23 Apr 2023

Abstract excerpt

Glioblastoma (GBM) is a highly aggressive and invasive brain tumor with a poor prognosis despite extensive treatment. The switch to aerobic glycolysis, known as the Warburg effect, in cancer cells leads to an increased production of methylglyoxal (MGO), a potent glycation agent with pro-tumorigenic characteristics. MGO non-enzymatically reacts with proteins, DNA, and lipids, leading to alterations in the...

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PMID: 37174618
DOI: 10.3390/cells12091219

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