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Article

Proteomics analysis of methylglyoxal‐induced neurotoxic effects in SH‐SY5Y cells

27 Dec 2010

Abstract excerpt

Reactive carbonyl compounds contribute to aging, Alzheimer's disease (AD) and other neurodegenerative diseases. Among these compounds, methylglyoxal (MG) can yield advanced glycation end products (AGEs), which are crucial in AD pathogenesis. However, the molecular and biochemical mechanisms of MG neurotoxicity are not completely understood. In the present study, SH-SY5Y cells were treated with MG to induce cell...

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PMID: 21264887
DOI: 10.1002/cbf.1714

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