Article

Endogenous Neurotoxicity: A Pathophysiological Consequence of Homeostatic Dysfunction

2026-07-09

Abstract excerpt

Neurotoxicity is generally thought to result from exogenous agents like environmental chemicals, drugs and biological toxins. However, increasing evidence suggests that many endogenous molecules that play a critical role in normal brain function can become neu-rotoxic when the regulatory mechanism involved in their production, metabolism, com-partmentalization and clearance are disrupted. This shift underlies the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cb5bd892-cdc2-5f66-9e74-714447a185b6
DOI: 10.20944/preprints202607.0686.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Endogenous Neurotoxicity: A Pathophysiological Consequence of Homeostatic DysfunctionDOI 10.20944/preprints202607.0686.v1Read

Environmental toxicants in the brain: A review of astrocytic metabolic dysfunctionSemantic proximity Read

Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?Semantic proximity Read

Redefining Roles: A Paradigm Shift in Tryptophan-Kynurenine Metabolism for Innovative Clinical ApplicationsSemantic proximity Read

Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?Semantic proximity Read

Neurodegenerative Diseases: Unraveling the Heterogeneity of Astrocytes.Semantic proximity Read

Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases—an updateSemantic proximity Read

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseasesSemantic proximity Read

Hyperammonemia-derived Neurovascular Inflammation Mediated by MAO-A and δ- Secretase in Neurodegenerative Brain ModelsSemantic proximity Read

Oxidative Stress, Neuroinflammation, and Microvascular Damage in Neurodegenerative Diseases: Mechanistic Insights and Therapeutic ApproachesSemantic proximity Read

Brain rust: Recent discoveries on the role of oxidative stress in neurodegenerative diseasesSemantic proximity Read

Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic ImplicationsSemantic proximity Read

Decoding Microglial Polarization and Metabolic Reprogramming in Neurodegenerative Diseases: Implications for Disease Progression and TherapySemantic proximity Read