Article

Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10

2022-11-24

Abstract excerpt

Classical cadherins, including vascular endothelial (VE)-cadherin, are targeted by matrix metalloproteinases (MMPs) and γ-secretase during adherens junction (AJ) disassembly, a mechanism that might have relevance for endothelial cell (EC) integrity and vascular homeostasis. Here, we show that oxidative stress triggered by H 2 O 2 exposure induced efficient VE-cadherin proteolysis by MMPs and γ-secretase in human...

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Literature Corpus work: 901eac92-6080-5245-a40e-424b4743352c
DOI: 10.1101/2022.11.23.517709

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