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Distinct biological events generated by ECM proteolysis by two homologous collagenases

14 Sept 2016

Abstract excerpt

It is well established that the expression profiles of multiple and possibly redundant matrix-remodeling proteases (e.g., collagenases) differ strongly in health, disease, and development. Although enzymatic redundancy might be inferred from their close similarity in structure, their in vivo activity can lead to extremely diverse tissue-remodeling outcomes. We observed that proteolysis of collagen-rich natural...

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PMID: 27630193
DOI: 10.1073/pnas.1519676113

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