Article

A FOXN1 mutation competitively displaces wild-type FOXN1 from higher-order nuclear condensates to cause immunodeficiency

2021-03-29

Abstract excerpt

The transcription factor FOXN1 is a master regulator of thymic epithelial cell development and function. Here we demonstrate that FOXN1 expression is differentially regulated during organogenesis and participates in multi-molecular nuclear condensates essential for the factor’s transcriptional activity. FOXN1’s C-terminal sequence regulates the diffusion velocity within these aggregates and modulates the binding t...

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Identifiers and source

Literature Corpus work: 9018274c-fdbb-5afa-bb62-d69d230a1ab4
DOI: 10.1101/2021.03.28.437237

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