Article
Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence.
PLoS genetics - 1 Nov 2011
Nowell Craig S, Bredenkamp Nicholas, Tetélin Stéphanie, Jin Xin, Tischner Christin, Vaidya Harsh, Sheridan Julie M, Stenhouse Frances Hogg, Heussen Raphaela, Smith Andrew J H, Blackburn C Clare
Abstract excerpt
The forkhead transcription factor Foxn1 is indispensable for thymus development, but the mechanisms by which it mediates thymic epithelial cell (TEC) development are poorly understood. To examine the cellular and molecular basis of Foxn1 function, we generated a novel and revertible hypomorphic allele of Foxn1. By varying levels of its expression, we identified a number of features of the Foxn1 system. Here we...
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