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Article

A natural allele of Nxf1 suppresses retrovirus insertional mutations.

Nature genetics - 1 Nov 2003

Floyd Jennifer A, Gold David A, Concepcion Dorothy, Poon Tiffany H, Wang Xiaobo, Keithley Elizabeth, Chen Dan, Ward Erica J, Chinn Steven B, Friedman Rick A, Yu Hon-Tsen, Moriwaki Kazuo, Shiroishi Toshihiko, Hamilton Bruce A

Abstract excerpt

Endogenous retroviruses have shaped the evolution of mammalian genomes. Host genes that control the effects of retrovirus insertions are therefore of great interest. The modifier-of-vibrator-1 locus (Mvb1) controls levels of correctly processed mRNA from genes mutated by endogenous retrovirus insertions into introns, including the Pitpn(vb) tremor mutation and the Eya1(BOR) model of human branchiootorenal...

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Share to Endogenous Retroviruses
Share to Genetic Complementation Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Introns

Share to Mice, Mutant Strains

Share to Mutagenesis, Insertional

Share to Repressor Proteins

Share to Sequence Homology, Amino Acid

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Source

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Identifiers

PMID: 14517553
DOI: 10.1038/ng1247
PMCID: PMC2756099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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