Article

Mapping the human epigenetic landscape across three generations: A DNA methylation resource from TMM BirThree

2025-08-20

Abstract excerpt

<title>Abstract</title> <p>Transgenerational epigenetic inheritance has been demonstrated in rodent models but not in humans. To address this gap, we established a comprehensive DNA methylation resource derived from 158 three-generation Japanese families. The dataset integrates genome-wide methylation profiles with extensive clinical and lifestyle data. Using targeted bisulfite sequencing, we profiled > 1 million...

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Literature Corpus work: 90034a7f-246b-5c51-a74a-14c19f2a8891
DOI: 10.21203/rs.3.rs-7314319/v1

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