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Article

Characterization of genome-methylome interactions in 22 nuclear pedigrees.

PloS one - 1 Jan 2014

Plongthongkum Nongluk, van Eijk Kristel R, de Jong Simone, Wang Tina, Sul Jae Hoon, Boks Marco P M, Kahn René S, Fung Ho-Lim, Ophoff Roel A, Zhang Kun

Abstract excerpt

Genetic polymorphisms can shape the global landscape of DNA methylation, by either changing substrates for DNA methyltransferases or altering the DNA binding affinity of cis-regulatory proteins. The interactions between CpG methylation and genetic polymorphisms have been previously investigated by methylation quantitative trait loci (mQTL) and allele-specific methylation (ASM) analysis. However, it remains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25019935
DOI: 10.1371/journal.pone.0099313
PMCID: PMC4096397

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MPO

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