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PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cells

2018-12-19

Abstract excerpt

Eukaryotic Primase-Polymerase (PrimPol) is an enzyme that maintains efficient DNA duplication by repriming replication restart downstream of replicase stalling lesions and structures. To elucidate the cellular requirements for PrimPol in human cells, we generated PrimPol-deleted cell lines and show that it plays key roles in maintaining active replication in both the nucleus and mitochondrion, even in the absence...

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Identifiers and source

Literature Corpus work
8ffb04a9-bf2b-5cc9-a219-74675fef2fa7
DOI
10.1101/501304
Open publication

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PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cellsDOI 10.1101/501304
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