Article

PrimPol variant V102A with altered primase and polymerase activities

2023-11-29

Abstract excerpt

PrimPol is a human DNA primase-polymerase which restarts DNA synthesis beyond DNA lesions and non-B DNA structures blocking replication. Disfunction of PrimPol in cells leads to slowing of DNA replication rates in mitochondria and nucleus, accumulation of chromosome aberrations, cell cycle delay, elevated sensitivity to DNA-damaging agents. PrimPol has been suggested to be associated with the development of ophtha...

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Literature Corpus work: c3b376c9-562d-515a-b27e-b9e1dab98c86
DOI: 10.1101/2023.11.29.569302

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