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Translesion DNA Synthesis and Reinitiation of DNA Synthesis in Chemotherapy Resistance

1 Aug 2020

Abstract excerpt

Many chemotherapy drugs block tumor cell division by damaging DNA. DNA polymerases eta (Pol η), iota (Pol ι), kappa (Pol κ), REV1 of the Y-family and zeta (Pol ζ) of the B-family efficiently incorporate nucleotides opposite a number of DNA lesions during translesion DNA synthesis. Primase-polymerase PrimPol and the Pol α-primase complex reinitiate DNA synthesis downstream of the damaged sites using their DNA...

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PMID: 33045948
DOI: 10.1134/s0006297920080039

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