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Article

Mitochondrial DNA replication: a PrimPol perspective.

Biochemical Society transactions - 15 Apr 2017

Bailey Laura J, Doherty Aidan J

Abstract excerpt

PrimPol, (primase-polymerase), the most recently identified eukaryotic polymerase, has roles in both nuclear and mitochondrial DNA maintenance. PrimPol is capable of acting as a DNA polymerase, with the ability to extend primers and also bypass a variety of oxidative and photolesions. In addition, PrimPol also functions as a primase, catalysing the preferential formation of DNA primers in a zinc finger-dependent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28408491
DOI: 10.1042/BST20160162
PMCID: PMC5390496

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