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PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cells

28 Jan 2019

Abstract excerpt

Eukaryotic Primase-Polymerase (PrimPol) is an enzyme that maintains efficient DNA duplication by repriming replication restart downstream of replicase stalling lesions and structures. To elucidate the cellular requirements for PrimPol in human cells, we generated PrimPol-deleted cell lines and show that it plays key roles in maintaining active replication in both the nucleus and mitochondrion, even in the absence...

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PMID: 30715459
DOI: 10.1093/nar/gkz056

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