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Article

Loss and revival of androgen receptor signaling in advanced prostate cancer

8 Jan 2021

Abstract excerpt

Targeting the androgen receptor (AR) signaling axis has been, over decades, the mainstay of prostate cancer therapy. More potent inhibitors of androgen synthesis and antiandrogens have emerged and have been successfully implemented in clinical practice. That said, the stronger inhibition of the AR signaling axis has led in recent years to an increase of prostate cancers that de-differentiate into AR-negative...

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PMID: 33420371
DOI: 10.1038/s41388-020-01598-0

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