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Aggressive variants of prostate cancer: underlying mechanisms of neuroendocrine transdifferentiation

2 Feb 2022

Abstract excerpt

Prostate cancer is a hormone-driven disease and its tumor cell growth highly relies on increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against androgen synthesis or AR activation is broadly used and continually improved. However, a subset of patients eventually progresses to castration-resistant disease. To date, various mechanisms of resistance have been identified including the...

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PMID: 35109899
DOI: 10.1186/s13046-022-02255-y

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