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Glucocerebrosidase in Parkinson's disease: Insights into pathogenesis and prospects for treatment

19 Apr 2016

Abstract excerpt

PD involves several converging pathogenetic pathways to neurodegeneration; highlighted in specific cases by genetic mutations causing familial PD. Numerically, the most important genetic mutations associated with PD are those of the glucocerebrosidase gene. Approximately 10% of PD patients carry glucocerebrosidase mutations. This observation has enhanced focus on the autophagy-lysosome system as important in...

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PMID: 27091307
DOI: 10.1002/mds.26616

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