Article
Glucocerebrosidase and Parkinson disease: Recent advances.
Molecular and cellular neurosciences - 1 May 2015
Schapira Anthony H V
Abstract excerpt
Mutations of the glucocerebrosidase (GBA) gene are the most important risk factor yet discovered for Parkinson disease (PD). Homozygous GBA mutations result in Gaucher disease (GD), a lysosomal storage disorder. Heterozygous mutations have not until recently been thought to be associated with any pathological process. However, it is clear that the presence of a GBA mutation in homozygous or heterozygous form is...
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