Article

Yeast surface display-based identification of ACE2 mutations that modulate SARS-CoV-2 spike binding across multiple mammalian species

2021-03-17

Abstract excerpt

Understanding how SARS-CoV-2 interacts with different mammalian angiotensin-converting enzyme II (ACE2) cell entry receptors elucidates determinants of virus transmission and facilitates development of vaccines for humans and animals. Yeast display-based directed evolution identified conserved ACE2 mutations that increase spike binding across multiple species. Gln42Leu increased ACE2-spike binding for human and fo...

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Literature Corpus work: 8fcee0ef-a167-51f4-a730-14a2551fc3d2
DOI: 10.1101/2021.03.16.435705

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