Article

Rapid characterization of spike variants via mammalian cell surface display

2021-03-30

Abstract excerpt

The SARS-CoV-2 spike (S) protein is a critical component of subunit vaccines and a target for neutralizing antibodies. Spike is also undergoing immunogenic selection with clinical variants that increase infectivity and partially escape convalescent plasma. Here, we describe spike display, a high-throughput platform to rapidly characterize glycosylated spike ectodomains across multiple coronavirus-family proteins....

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Literature Corpus work: 53bfda2c-49c0-52d9-857b-0d686c415196
DOI: 10.1101/2021.03.30.437622

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