Article

Reverse regression increases power for detecting trans-eQTLs

2020-05-09

Abstract excerpt

Trans-acting expression quantitative trait loci (trans-eQTLs) are genetic variants affecting the expression of distant genes. They account for ≥70% expression heritability and could therefore facilitate uncovering mechansisms underlying the origination of complex diseases. However, unlike cis-eQTLs, identifying trans-eQTLs is challenging because of small effect sizes, tissue-specificity, and the severe multiple-te...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 83b47afc-087e-5b4d-a887-22186ec7727d
DOI: 10.1101/2020.05.07.083386

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reverse regression increases power for detecting trans-eQTLsDOI 10.1101/2020.05.07.083386Read

Tejaas: reverse regression increases power for detecting trans-eQTLs.Semantic proximity Read

Distant regulatory effects of genetic variation in multiple human tissuesSemantic proximity Read

Imputed gene associations identify replicable <i>trans</i> -acting genes enriched in transcription pathways and complex traitsSemantic proximity Read

Leveraging genome-wide effects on gene expression to identify disease-critical genes with <i>trans</i> -genetic componentsSemantic proximity Read

Local genetic effects on gene expression across 44 human tissuesSemantic proximity Read

Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMedSemantic proximity Read

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.Semantic proximity Read

Enhancing Disease Risk Gene Discovery by Integrating Transcription Factor-Linked Trans-located Variants into Transcriptome-Wide Association AnalysesSemantic proximity Read

<i>Trans</i> -eQTLs reveal the architecture of human gene regulatory networksSemantic proximity Read

Joint eQTL mapping and inference of gene regulatory network improves power of detecting both cis- and trans-eQTLs.Semantic proximity Read

Enhancing disease risk gene discovery by integrating transcription factor-linked trans-variants into transcriptome-wide association analyses.Semantic proximity Read

Types of cis- and trans-gene regulation of expression quantitative trait loci across human tissuesSemantic proximity Read