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Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits

15 Nov 2022

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) has been a global health concern since 2019. The viral spike protein infects the host by binding to angiotensin-converting enzyme 2 (ACE2) expressed on the cell surface, which is then processed by type II transmembrane serine protease. However, ACE2 does not react to SARS-CoV-2 in inbred wild-type mice, which...

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PMID: 36457995
DOI: 10.3389/fimmu.2022.1055811

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