Article

Partitioning gene-mediated disease heritability without eQTLs

2021-07-14

Abstract excerpt

Unknown SNP-to-gene regulatory architecture complicates efforts to link noncoding GWAS associations with genes implicated by sequencing or functional studies. eQTLs are used to link SNPs to genes, but expression in bulk tissue explains a small fraction of disease heritability. A simple but successful approach has been to link SNPs with nearby genes, but the fraction of heritability mediated by these genes is uncle...

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Literature Corpus work: 8fa1b30a-e50c-587e-95cd-ad94bd2c539f
DOI: 10.1101/2021.07.14.452393

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