Article

Dopamine-iron homeostasis interaction rescues mitochondrial fitness in Parkinson’s disease

2023-12-20

Abstract excerpt

<h4>ABSTRACT</h4> Imbalances of iron and dopamine metabolism along with mitochondrial dysfunction have been linked to the pathogenesis of Parkinson’s disease (PD). We have previously suggested a direct link between iron homeostasis and dopamine metabolism, as dopamine can increase cellular uptake of iron into macrophages thereby promoting oxidative stress responses. In this study, we investigated the interplay be...

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Literature Corpus work: 8f91e4e6-47ad-5979-806d-34c235b6406e
DOI: 10.1101/2023.12.19.572356

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