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Article

Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential

11 Nov 2023

Abstract excerpt

Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial dysfunction, including antioxidants, antidiabetic drugs, and iron chelators, have failed in disease-modification clinical trials. In this review, we summarize the cellular determinants of mitochondrial dysfunction, including impairment of...

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PMID: 37951933
DOI: 10.1186/s13024-023-00676-7

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