Article

Structural Basis for Membrane Recruitment of ATG16L1 by WIPI2 in Autophagy

2021-05-14

Abstract excerpt

<h4>ABSTRACT</h4> Autophagy is a cellular process that degrades cytoplasmic cargo by engulfing it in a double membrane vesicle, known as the autophagosome, and delivering it to the lysosome. The ATG12–5-16L1 complex is responsible for conjugating members of the ubiquitin-like ATG8 protein family to phosphatidylethanolamine in the growing autophagosomal membrane, known as the phagophore. ATG12–5-16L1 is recruited...

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Literature Corpus work: 8f6f992d-1a42-51c7-a060-a295bfffcd3b
DOI: 10.1101/2021.05.14.444175

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