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Article

A conserved ATG2 binding site in WIPI4 and yeast Hsv2 is disrupted by mutations causing β-propeller protein-associated neurodegeneration.

Human molecular genetics - 17 Dec 2021

Bueno-Arribas Miranda, Blanca Irene, Cruz-Cuevas Celia, Escalante Ricardo, Navas María-Angeles, Vincent Olivier

Abstract excerpt

PROPPINs are phosphoinositide-binding β-propeller proteins that mediate membrane recruitment of other proteins and are involved in different membrane remodeling processes. The main role of PROPPINs is their function in autophagy, where they act at different steps in phagophore formation. The human PROPPIN WIPI4 (WDR45) forms a complex with ATG2 involved in phagophore elongation, and mutations in this gene cause...

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PMID: 34368840
DOI: 10.1093/hmg/ddab225
PMCID: PMC8682751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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