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Article

WIPI1 promotes fission of endosomal transport carriers and formation of autophagosomes through distinct mechanisms

8 Mar 2021

Abstract excerpt

Autophagosome formation requires PROPPIN/WIPI proteins and monophosphorylated phosphoinositides, such as phosphatidylinositol-3-phosphate (PtdIns3P) or PtdIns5P. This process occurs in association with mammalian endosomes, where the PROPPIN WIPI1 has additional, undefined roles in vesicular traffic. To explore whether these functions are interconnected, we dissected routes and subreactions of endosomal...

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PMID: 33685363
DOI: 10.1080/15548627.2021.1886830

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