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Article

WIPI proteins: essential PtdIns3<i>P</i> effectors at the nascent autophagosome

1 Jan 2015

Abstract excerpt

Autophagy is a pivotal cytoprotective process that secures cellular homeostasis, fulfills essential roles in development, immunity and defence against pathogens, and determines the lifespan of eukaryotic organisms. However, autophagy also crucially contributes to the development of age-related human pathologies, including cancer and neurodegeneration. Macroautophagy (hereafter referred to as autophagy) clears the...

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PMID: 25568150
DOI: 10.1242/jcs.146258

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