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Article

Multi-site-mediated entwining of the linear WIR-motif around WIPI β-propellers for autophagy.

Nature communications - 1 Jun 2020

Ren Jinqi, Liang Ruobing, Wang Wenjuan, Zhang Dachuan, Yu Li, Feng Wei

Abstract excerpt

WIPI proteins (WIPI1-4) are mammalian PROPPIN family phosphoinositide effectors essential for autophagosome biogenesis. In addition to phosphoinositides, WIPI proteins can recognize a linear WIPI-interacting-region (WIR)-motif, but the underlying mechanism is poorly understood. Here, we determine the structure of WIPI3 in complex with the WIR-peptide from ATG2A. Unexpectedly, the WIR-peptide entwines around the...

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Identifiers

PMID: 32483132
DOI: 10.1038/s41467-020-16523-y
PMCID: PMC7264293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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