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Article

Crystal structure of the Rab33B/Atg16L1 effector complex.

Scientific reports - 31 Jul 2020

Metje-Sprink Janina, Groffmann Johannes, Neumann Piotr, Barg-Kues Brigitte, Ficner Ralf, Kühnel Karin, Schalk Amanda M, Binotti Beyenech

Abstract excerpt

The Atg12-Atg5/Atg16L1 complex is recruited by WIPI2b to the site of autophagosome formation. Atg16L1 is an effector of the Golgi resident GTPase Rab33B. Here we identified a minimal stable complex of murine Rab33B(30-202) Q92L and Atg16L1(153-210). Atg16L1(153-210) comprises the C-terminal part of the Atg16L1 coiled-coil domain. We have determined the crystal structure of the Rab33B Q92L/Atg16L1(153-210)...

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Identifiers

PMID: 32737358
DOI: 10.1038/s41598-020-69637-0
PMCID: PMC7395093

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