SpeciefAI: Multi-species mRNA-level Antibody Framework Generation using Transformers

Abstract excerpt

<h4>Motivation</h4> Encoding antibodies (Abs) and nanobodies (Nbs) as mRNA enables in vivo production of therapeutic proteins. However, this approach requires meeting two species-dependent requirements: the mRNA encoding must support efficient expression in the host species, and the encoded protein sequence must resemble the natural Ab repertoire of the recipient species to minimize immunogenicity. These requirem...

Topics

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• Mutation
• Amino Acid Sequence
• Antibodies
• Chronic Lymphocytic Leukemia Research
• Computational Biology
• Germ-Line Mutation
• Glycosylation and Glycoproteins Research
• Monoclonal and Polyclonal Antibodies Research

Identifiers and source

Literature Corpus work

8f6ac802-3e20-5520-8152-6cf80519f38a

DOI

10.64898/2026.03.16.712018