DoggifAI: a transformer based approach for antibody caninisation

Abstract excerpt

Antibody translation across species offers a compelling strategy to extend the vast and expensive investments in human therapeutic antibodies to veterinary oncology, with applications in both veterinary medicine and comparative oncology. While precise, low-immunogenic treatments are essential for canine cancer care, traditional species conversion methods rely on ad hoc bioinformatics modifications. These methods o...

Topics

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• Amino Acid Sequence
• Antibodies
• Chronic Lymphocytic Leukemia Research
• Computational Biology
• Germ-Line Mutation
• Glycosylation and Glycoproteins Research
• Monoclonal and Polyclonal Antibodies Research
• Mutation

Identifiers and source

Literature Corpus work

8d7fb478-5eb5-5707-b481-1c90f7508e4c

DOI

10.1101/2025.05.28.656573