Article

Suppression of astrocyte BMP signaling improves fragile X syndrome molecular signatures and functional deficits

2024-06-24

Abstract excerpt

Fragile X syndrome (FXS) is a monogenic neurodevelopmental disorder with manifestations spanning molecular, neuroanatomical, and behavioral changes. Astrocytes contribute to FXS pathogenesis and show hundreds of dysregulated genes and proteins; targeting upstream pathways mediating astrocyte changes in FXS could therefore be a point of intervention. To address this, we focused on the bone morphogenetic protein (BM...

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Literature Corpus work: 8f69d658-536c-5d64-ba80-585f73e4933e
DOI: 10.1101/2024.06.19.599752

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