Article

Aberrant astrocyte protein secretion contributes to altered neuronal development in diverse disorders

2020-02-17

Abstract excerpt

Astrocytes negatively impact neuronal development in many neurodevelopmental disorders (NDs), however how they do this, and if mechanisms are shared across disorders, is not known. We developed an in vitro system to ask how astrocyte protein secretion and gene expression change in three genetic NDs. We identified disorder specific changes, and changes common to all disorders. ND astrocytes increase release of Igfb...

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Literature Corpus work: 47e2075f-b9fb-51f1-93a3-47154c4cf615
DOI: 10.1101/2020.02.17.939991

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