Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies B2M Inactivation Impairing Immunorecognition.

doi:10.1158/1078-0432.CCR-16-1946

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Article

Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies B2M Inactivation Impairing Immunorecognition.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2017

Pereira Carolina, Gimenez-Xavier Pol, Pros Eva, Pajares Maria J, Moro Massimo, Gomez Antonio, Navarro Alejandro, Condom Enric, Moran Sebastian, Gomez-Lopez Gonzalo, Graña Osvaldo, Rubio-Camarillo Miriam, Martinez-Martí Alex, Yokota Jun, Carretero Julian, Galbis Jose M, Nadal Ernest, Pisano David, Sozzi Gabriella, Felip Enriqueta, Montuenga Luis M, Roz Luca, Villanueva Alberto, Sanchez-Cespedes Montse

Abstract excerpt

Purpose: We aimed to maximize the performance of detecting genetic alterations in lung cancer using high-throughput sequencing for patient-derived xenografts (PDXs).Experimental Design: We undertook an integrated RNA and whole-exome sequencing of 14 PDXs. We focused on the genetic and functional analysis of β2-microglobulin (B2M), a component of the HLA class-I complex.Results: We identified alterations in genes...

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Identifiers

PMID: 28302866
DOI: 10.1158/1078-0432.CCR-16-1946

Genes

CALR
PDIA3
TAP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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