Article
B cell phenotypes and antibody signatures associate with interpatient variation in the lung adenocarcinoma tumor microenvironment.
Frontiers in immunology - 1 Jan 2025
Rasche Kamille M, Tieri David, Morrissey Samantha M, Li Hong, Zhang Fan, Gibson William S, Ford Easton E, Jana Uddalok, Smith Melissa L, Yan Jun, Watson Corey T
Abstract excerpt
Introduction: Non-small cell lung cancer is the leading cause of cancer-related mortality worldwide, with lung adenocarcinoma (LUAD) as the most common subtype. Although early-stage disease is often treated surgically, advanced LUAD typically requires chemotherapy, radiation, and/or immunotherapy, largely focused on T cell-mediated responses. Therapeutic efficacy, however, is also shaped by tumor-infiltrating...
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