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DNA damage repair gene alterations influence the tumor immune microenvironment in advanced non-small cell lung cancer

15 Feb 2025

Abstract excerpt

Purpose DNA damage response and repair (DDR) gene alterations contribute to genomic instability and increased tumor immunogenicity, yet their clinical significance in non-small cell lung cancer (NSCLC) remains unclear. Using a large real-world dataset, we evaluated the prevalence of DDR alterations and their relation to the tumor immune microenvironment in metastatic NSCLC. Experimental design We retrospectively...

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PMID: 39961190
DOI: 10.1016/j.lungcan.2025.108444

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