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DNA damage repair gene alterations influence the tumor immune microenvironment in advanced non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Mar 2025

Sankar Kamya, Mercer Jacob, Jaeger Ellen B, Godden Jen, Williams Edward, Thompson Michael A, Patel Shetal A, Figueiredo Jane C, Weinberg Frank, Reckamp Karen L

Abstract excerpt

PURPOSE: DNA damage response and repair (DDR) gene alterations contribute to genomic instability and increased tumor immunogenicity, yet their clinical significance in non-small cell lung cancer (NSCLC) remains unclear. Using a large real-world dataset, we evaluated the prevalence of DDR alterations and their relation to the tumor immune microenvironment in metastatic NSCLC. EXPERIMENTAL DESIGN: We...

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PMID: 39961190
DOI: 10.1016/j.lungcan.2025.108444

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