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Article

Molecular architecture of the tumor microenvironment caused by BRCA1 and BRCA2 somatic mutations in human lung adenocarcinoma.

eLife - 26 May 2026

Liao Gaoming, Yang Xinbin, Liu Qi, Nan Shufeng, Liu Yan, Li Jinwei, Huang Si, Ning Wang, Qin Xionghai, Xu Gang

Abstract excerpt

Homologous recombination repair (HRR) deficiency is associated with improved immunotherapy responses in non-small cell lung cancer (NSCLC) patients. The HRR genes BRCA1/2 are key regulators of DNA repair, yet their impact on the tumor microenvironment (TME) in lung adenocarcinoma (LUAD) remains unclear. Using single-cell sequencing and multi-omics data, we characterized BRCA1/2 mutation-associated transcriptional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42189716
DOI: 10.7554/eLife.110662
PMCID: PMC13211877

Genes

BRCA1
BRCA2
CD4
CD28

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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